Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080

Turkish Journal of Vascular Surgery 2019 , Vol 28 , Issue 1
Serum SCUBE-1 levels can predict endothelial dysfunction in healthy young adults
Mustafa Etli1, Oğuz Karahan2
1Department of Cardiovascular Surgery, Yalvac State Hospital, Isparta, Turkey
2Department of Cardiovascular Surgery, Medical School of Dicle University, Diyarbakır, Turkey
DOI : 10.9739/tjvs.2019.299 Objectives: This study aims to investigate the predictive role of the signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1) in the presence of endothelial dysfunction.

Patients and methods: Between December 2014 and August 2015, 120 healthy young adults (68 males, 52 females; mean age 29.7±4.1 years; range, 20 to 35 years) without a previous history of cardiovascular disease were included. The participants were divided into two groups according to normal (n=73) and abnormal flow-mediated dilatation (FMD) response (n=47). Simultaneously, the standard biochemical markers, blood urea-nitrogen, creatinine, liver enzymes, glucose, lipids and SCUBE-1 levels were determined from the blood samples.

Results: Multivariable logistic regression revealed a strong association between SCUBE-1 and FMD (p<0.001). We found that for a cut-off point of >136.37 ng/mL, SCUBE-1 had 85.0% sensitivity and 81.2% specificity to identify abnormal FMD.

Conclusion: Our study findings indicate that there is a favorable inverse correlation between the SCUBE-1 and FMD. Keywords : Atherosclerosis progression; endothelial dysfunction; flow-mediated vasodilatation; SCUBE-1.